Clinical, morphologic, and genomic findings in ROS1 fusion Spitz neoplasms
نویسندگان
چکیده
منابع مشابه
Molecular pathways: ROS1 fusion proteins in cancer.
Genetic alterations that lead to constitutive activation of kinases are frequently observed in cancer. In many cases, the growth and survival of tumor cells rely upon an activated kinase such that inhibition of its activity is an effective anticancer therapy. ROS1 is a receptor tyrosine kinase that has recently been shown to undergo genetic rearrangements in a variety of human cancers, includin...
متن کاملHypopigmented atypical Spitzoid neoplasms (atypical Spitz nevi, atypical Spitz tumors, Spitzoid melanoma): a clinicopathological update
The clinicopathologic classification, diagnosis, and management of Spitzoid melanocytic lesions is one of the most problematic topics in dermato-oncology and dermatopathology. After earlier anecdotal reports [1,2], the controversial history of these controversial lesions began in 1948 when Sophie Spitz described 13 cases of what she called “juvenile melanoma,” underlining its presumably good pr...
متن کاملMolecular Pathways Molecular Pathways: ROS1 Fusion Proteins in Cancer
Genetic alterations that lead to constitutive activation of kinases are frequently observed in cancer. In many cases, the growth and survival of tumor cells rely upon an activated kinase such that inhibition of its activity is an effective anticancer therapy. ROS1 is a receptor tyrosine kinase that has recently been shown toundergo genetic rearrangements in a variety of human cancers, including...
متن کاملbreast ductal carcinoma in situ: morphologic and kinetic mri findings
conclusion non-mass-like lesions, lesions with focal or segmental distribution, with a “plateau” enhancement curve type were the most frequent findings of dcis lesions on mri. background adequate diagnosis of ductal carcinoma in situ (dcis) could lead to efficacious treatment. due to the fact that dcis lesions can progress to invasive carcinomas and that the sensitivity of the standard examinat...
متن کاملMorphologic and molecular genetic aspects of oligodendroglial neoplasms.
Morphologic criteria for diagnosing oligodendrogliomas and for classifying them as well-differentiated (World Health Organization grade II) and anaplastic (World Health Organization grade III) are well recognized. Nevertheless, applying these guidelines to specific cases often reveals discrepancies among different observers. In addition, whether a given tumor also contains an astrocytic compone...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Modern Pathology
سال: 2020
ISSN: 0893-3952,1530-0285
DOI: 10.1038/s41379-020-00658-w